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If so, the data provided is not processed for the Brief Profile. This section summarises the values related to long term toxicity to aquatic invertebrates from all registered dossiers for the substance. Please note that it may take a week or two to have everything fully in place, and please be aware in the meantime that the Registration status may be incorrect and the CLP regulatory context may be incompletely shown. It is possible that the harmonisation is introduced through an amendment to the CLP Regulation. It is a monohydroxybenzoic acid and a methoxybenzoic acid.It is a conjugate acid of a vanillate. 1.3), Very insensitive substances with mass explosion hazard (Div. Downregulation of melanogenesis: drug discovery and therapeutic options. EC10 / LC10 or NOEC for marine water invertebrates provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water invertebrates or the no observed effect concentration for marine water invertebrates. Critical property indentification: Where less than 90% of the notifiers provide the same classification to derive the critical property, the border of this critical property icon is displayed as dashed. Therefore, data has to fit the format and aggregation logic that is used for the Brief Profile. A dopaminergic hyperfunction in schizophrenia, as originally postulated, has been found in the striatum of patients using a variety of techniques. For example CLH index numbers, CN numbers, deleted CAS numbers, etc. Long-term EC10 or LC10 or NOEC for soil microorganisms provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the soil microorganisms in the test, or the no observed effect concentration for soil microorganisms.

The Metabolomics Innovation Centre (TMIC), Creative Commons Attribution-NonCommercial 4.0 International License.

The ‘Scientific properties’ section gives an overview of summarised scientific data from registered dossiers. 2020 Jul 24;10(8):1098. doi: 10.3390/biom10081098. The CoRAP list includes substances that could pose a risk to human health or the environment and whose (potentially hazardous) properties are to be evaluated by the Member States in the next three years. The Good Scents Company (2009). The date of the last update corresponds to the publication date of the Brief Profile and not necessarily to the date in which the update occurred in the source data (registered dossiers, the C&L Inventory or a regulatory process). The information provided in the free-text fields is not published in the Brief Profiles. Compare with cathartic, which is a substance that accelerates defecation. The sixth degradation product could not be identified with available references, but had the empirical formula of C13H8O4. The % is based on count of values provided. Octaphlorethol A isolated from Ishige foliacea inhibits α-MSH-stimulated induced melanogenesis via ERK pathway in B16F10 melanoma cells. The IUPAC nomenclature is a systematic way of naming chemical substances, both organic and inorganic. Values are generally displayed in milligram per litre.

If additional information derived from classification and labelling (C&L) notifications to ECHA under the CLP Regulation exists, this will be displayed below the information derived from harmonised classification and labelling and REACH registrations. Nishina A, Ebina K, Ukiya M, Fukatsu M, Koketsu M, Ninomiya M, Sato D, Kimura H. J Food Sci. However, EC was significantly less effective than EGCG, which has a B-ring pyrogallol group instead of a catechol group, and a gallate unit esterified to C-ring EC.50 EGCG was found to reduce 150 times more α-tocopheroxyl radical than an equal molar concentration of EC, although EGCG was found to be less effective in reducing α-tocopheroxyl radicals than ascorbyl palmitate, a lipophilic ascorbate analog. Natural Products >> Acids and Aldehydes. Zhou et al.55 reported that green tea catechins reduce α-tocopheroxyl radical to regenerate α-tocopherol with increasing rate constants of 0.43, 0.45, 1.11, 1.31 and 1.91×102 M−1 s−1 for GA, EC, EGC, ECG, and EGCG, respectively, in sodium dodecyl sulfate micelles. The aim is to display the lowest values reported as causing the most adverse effects, and hence the broadest possible safety margins for the substance. EC/LC50 for freshwater plants provides substance information on the substance’s effect concentration or lethal concentration for 50% of the freshwater plants in the test, generally displayed in milligram per litre. in case of consumer and professional uses). Values are generally displayed in milligram per kilo food. Short-term EC50 or LC50 for terrestrial plants provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of the terrestrial plants in the test, generally displayed in milligram per kilo soil (dry weight).

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